Description
General Description
DSPE-Aldehyde is a reactive phospholipid derivative containing DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine, C18:0) and a terminal aldehyde functional group. The aldehyde functionality enables selective conjugation with amine- and hydrazide-containing molecules through Schiff base formation and reductive amination reactions.
Key Properties
- Aldehyde-functionalized phospholipid
- Reactive terminal aldehyde group
- DSPE phospholipid anchor (C18:0)
- Saturated lipid structure for enhanced membrane stability
- Suitable for liposome and nanoparticle functionalization
Applications
- Liposome surface modification
- Lipid nanoparticle engineering
- Biomolecule conjugation
- Antibody and peptide conjugation
- Drug and nucleic acid delivery
- Nanomedicine and biomaterial applications
Functional Overview
The DSPE lipid segment provides stable membrane incorporation, while the aldehyde functionality enables selective conjugation with amine- and hydrazide-containing biomolecules and polymers.
Summary
DSPE-ALD is a versatile reactive phospholipid widely used in liposome engineering, nanoparticle functionalization, and advanced nanomedicine applications.
