Description
General Description
DSPE-NHS is a reactive phospholipid derivative containing DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine, C18:0) and an N-hydroxysuccinimide (NHS) ester functional group. The NHS ester readily reacts with primary amines under mild conditions to form stable amide bonds for bioconjugation and surface modification applications.
Key Properties
- NHS ester-functionalized phospholipid
- Highly reactive toward primary amines
- DSPE phospholipid anchor (C18:0)
- Saturated lipid structure for enhanced membrane stability
- Suitable for liposome and nanoparticle functionalization
Applications
- Amine-reactive bioconjugation
- Liposome surface modification
- Lipid nanoparticle engineering
- Protein and peptide conjugation
- Drug and nucleic acid delivery
- Nanomedicine and biomaterial applications
Functional Overview
The DSPE lipid segment provides stable membrane incorporation, while the NHS ester functionality enables efficient conjugation with amine-containing biomolecules, polymers, and nanoparticle surfaces.
Summary
DSPE-NHS is a versatile amine-reactive phospholipid widely used in liposome engineering, nanoparticle functionalization, and advanced nanomedicine applications.
