Description
General Description
DSPE-PEG-Alkyne is a phospholipid–poly(ethylene glycol) conjugate containing DSPE (distearoyl phosphoethanolamine), a hydrophilic PEG spacer, and a terminal alkyne functional group. The alkyne group enables bioorthogonal click chemistry conjugation with azide-containing molecules.
Key Properties
- Alkyne-functionalized lipid PEG conjugate
- Suitable for click chemistry reactions (CuAAC / SPAAC-compatible systems)
- DSPE lipid anchor for membrane incorporation
- PEG spacer improves aqueous solubility and steric stabilization
- Biocompatible lipid–polymer hybrid material
Applications
- Liposome and lipid nanoparticle functionalization
- Click chemistry bioconjugation
- Surface modification of nanoparticles and biomaterials
- Targeted drug delivery system development
- Hydrogel and polymer conjugation
- Diagnostic and imaging applications
Functional Overview
The DSPE lipid segment anchors into lipid bilayers, while PEG provides flexibility and stealth properties. The terminal alkyne group enables selective conjugation with azide-functionalized molecules through click chemistry reactions.
Summary
DSPE-PEG-Alkyne is a versatile click-functional lipid PEG conjugate widely used in lipid nanoparticle engineering, bioconjugation, and advanced drug delivery applications.
