Description
General Description
DSPE-PEG-Biotin is a versatile lipid-PEG conjugate designed for membrane anchoring and streptavidin-mediated conjugation. The DSPE lipid anchor readily incorporates into liposomal membranes and lipid nanoparticle formulations, while the PEG spacer extends into the aqueous environment, improving colloidal stability, reducing nonspecific interactions, and enhancing circulation properties.
The terminal biotin group binds strongly and selectively to streptavidin, avidin, and neutravidin, enabling efficient attachment of proteins, antibodies, enzymes, nucleic acids, imaging agents, and other biomolecules. DSPE-PEG-Biotin is widely used in liposome engineering, targeted nanomedicine, diagnostic assays, biosensing, and biofunctionalized nanoparticle development.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Streptavidin-mediated conjugation
- Avidin-biotin binding systems
- Targeted drug delivery
- Antibody immobilization
- Protein conjugation
- Diagnostic applications
- Biosensor development
- Nanomedicine research
Features and Benefits
- DSPE anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Biotin ligand for streptavidin binding
- Strong and specific avidin-biotin interaction
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Enables versatile biomolecule immobilization
- Available in multiple PEG molecular weights
