MPEG-PLGA-NH2 structure

MPEG-PLGA-NH2

Price range: $200.00 through $600.00

MPEG-PLGA-NH2 is a biodegradable diblock copolymer composed of methoxy polyethylene glycol (MPEG) and poly(D,L-lactide-co-glycolide) (PLGA) terminated with a primary amine group. The polymer combines the hydrophilicity of MPEG with the biodegradability of PLGA while providing a reactive amine functionality for conjugation to peptides, proteins, antibodies, fluorophores, and other biomolecules. MPEG-PLGA-NH2 is widely used in nanoparticle formulation, drug delivery, and biomaterials research.

roduct Name: MPEG-PLGA-NH2
Polymer Composition: Methoxy Polyethylene Glycol-block-Poly(D,L-lactide-co-glycolic acid)-Amine
Molecular Weight: Various MPEG and PLGA molecular weights available
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Functional Groups: MPEG, PLGA, Amine (NH2)
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, Acetone, THF, Dichloromethane, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

MPEG-PLGA-NH2 structure

SKU: 12728 Categories: , ,

Description

General Description

MPEG-PLGA-NH2 is an amphiphilic block copolymer consisting of a hydrophilic MPEG segment and a biodegradable PLGA segment terminated with a primary amine group. The MPEG block improves aqueous stability, prolongs circulation time, and enhances biocompatibility, while the PLGA block enables controlled biodegradation and hydrophobic drug encapsulation.

The terminal amine group readily reacts with activated esters, carboxylic acids, aldehydes, isocyanates, and other amine-reactive molecules, enabling efficient bioconjugation and surface functionalization. MPEG-PLGA-NH2 readily self-assembles into polymeric micelles and nanoparticles in aqueous environments and is widely used for targeted drug delivery, nanoparticle modification, imaging probe development, and advanced biomaterials applications.

Applications

  • Polymeric nanoparticle preparation
  • Drug delivery systems
  • Controlled drug release
  • Targeted drug delivery
  • Peptide conjugation
  • Protein conjugation
  • Antibody conjugation
  • Surface modification
  • Nanomedicine research
  • Biomaterials development

Features and Benefits

  • Biodegradable PLGA segment
  • Hydrophilic MPEG segment
  • Reactive primary amine functionality
  • Compatible with NHS ester coupling chemistry
  • Self-assembles into nanoparticles and micelles
  • Excellent biocompatibility
  • Suitable for hydrophobic drug encapsulation
  • Controlled degradation profile
  • Available in multiple MPEG and PLGA molecular weights

Additional information

PLGA Molecular Weight

2K, 5K, 10K
PEG Molecular Weight

1K, 2K, 5K
Package Size

100mg, 1g

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