Description
General Description
PLGA Diacid is a biodegradable polyester synthesized from D,L-lactide and glycolide and terminated with carboxylic acid groups at both ends of the polymer chain. The polymer combines the excellent biodegradability and biocompatibility of PLGA with highly reactive carboxyl functionalities suitable for further chemical modification.
The terminal carboxyl groups can be activated using carbodiimide chemistry (EDC/NHS) and subsequently conjugated with amines, peptides, proteins, PEG derivatives, targeting ligands, and therapeutic molecules. PLGA Diacid serves as an important intermediate for the synthesis of functional block copolymers, targeted drug delivery systems, nanoparticles, and biodegradable biomaterials.
Applications
- Drug delivery systems
- Nanoparticle preparation
- Polymer conjugation
- PEGylated copolymer synthesis
- Peptide conjugation
- Protein conjugation
- Surface modification
- Tissue engineering
- Controlled release formulations
- Biomaterials research
Features and Benefits
- Carboxylic acid groups at both chain ends
- Biodegradable and biocompatible
- Excellent reactive polymer intermediate
- Suitable for EDC/NHS coupling chemistry
- Controlled degradation profile
- Versatile conjugation capability
- Supports synthesis of functional copolymers
- Widely used in biomedical applications
- Available in various molecular weights and lactide:glycolide ratios
