Description
General Description
PLGA-di-Biotin is a biodegradable polyester derived from D,L-lactide and glycolide and functionalized with biotin moieties at both termini. The PLGA backbone provides excellent biodegradability and biocompatibility, while the biotin groups offer strong and selective affinity interactions with streptavidin, avidin, and neutravidin.
The combination of biodegradable PLGA and biotin functionality makes PLGA-di-Biotin particularly useful for the preparation of targeted nanoparticles, drug delivery systems, imaging probes, and biofunctional materials. Through the well-established biotin-streptavidin interaction, the polymer enables efficient immobilization, surface modification, and assembly of complex biomaterials for pharmaceutical, diagnostic, and biomedical applications.
Applications
- Targeted drug delivery
- Nanoparticle functionalization
- Streptavidin-mediated conjugation
- Avidin-biotin binding systems
- Biosensor development
- Diagnostic assays
- Surface modification
- Biomedical imaging
- Tissue engineering
- Biomaterials research
Features and Benefits
- Biotin groups at both chain ends
- Strong affinity for streptavidin and avidin
- Biodegradable and biocompatible PLGA backbone
- Suitable for targeted delivery systems
- Enables efficient surface immobilization
- Supports biomolecule conjugation
- Controlled degradation profile
- Compatible with nanoparticle fabrication
- Available in various molecular weights and lactide:glycolide ratios
