Description
General Description
PDLLA-Thiol (PDLLA-SH) is a functional aliphatic polyester derived from D,L-lactide. Unlike crystalline PLLA, PDLLA is amorphous, resulting in more uniform degradation behavior and broader applicability in pharmaceutical and biomedical applications.
The terminal thiol group readily reacts with maleimides, vinyl sulfones, acrylates, and activated disulfides, enabling efficient conjugation with peptides, proteins, antibodies, fluorophores, nanoparticles, and targeting ligands. PDLLA-SH is frequently employed in nanoparticle preparation, polymer-drug conjugates, biodegradable implants, hydrogel formation, tissue engineering scaffolds, and controlled drug delivery systems.
Applications
- Drug delivery systems
- Nanoparticle formulation
- Polymer-drug conjugates
- Tissue engineering
- Biodegradable implants
- Surface modification
- Protein conjugation
- Peptide conjugation
- Hydrogel preparation
- Biomaterials research
Features and Benefits
- Biodegradable PDLLA backbone
- Amorphous polymer structure
- Reactive thiol functionality
- Excellent biocompatibility
- Controlled degradation behavior
- Suitable for thiol-specific bioconjugation
- Easy chemical modification
- Pharmaceutical-grade polymer platform
- Available in multiple molecular weights
