Description
General Description
PEI-g-PEG-SH is a multifunctional polymer conjugate composed of polyethyleneimine (PEI), polyethylene glycol (PEG), and terminal thiol (-SH) groups. The PEI backbone provides cationic charge for nucleic acid complexation, PEG improves biocompatibility and colloidal stability, and the thiol group enables selective conjugation with maleimide-, gold-, and disulfide-reactive systems.
Key Properties
- Cationic PEI-based polymer conjugate
- PEGylated structure improves aqueous stability and biocompatibility
- Terminal thiol (-SH) functionality
- Suitable for nucleic acid delivery and nanoparticle engineering
- Multifunctional drug delivery material
Applications
- Gene and nucleic acid delivery
- siRNA and mRNA delivery research
- Thiol-mediated bioconjugation
- Nanoparticle surface functionalization
- Gold nanoparticle modification
- Drug delivery and nanomedicine applications
Functional Overview
The PEI segment provides electrostatic interaction with negatively charged nucleic acids, while PEG improves steric stabilization and reduces aggregation. The terminal thiol group enables selective conjugation with thiol-reactive molecules and surfaces.
Summary
PEI-g-PEG-SH is a versatile multifunctional polymer conjugate widely used in gene delivery, nanomedicine, and advanced bioconjugation applications.
