Description
General Description
PLLA-Amine (PLLA-NH2) is a functional aliphatic polyester derived from L-lactide. Unlike amorphous PDLLA, PLLA possesses a semi-crystalline structure, resulting in higher mechanical strength, improved thermal properties, and slower degradation behavior.
The terminal primary amine group serves as a versatile handle for conjugation with NHS esters, activated carboxylic acids, aldehydes, isothiocyanates, fluorophores, peptides, proteins, antibodies, and targeting ligands. PLLA-NH2 is frequently employed in nanoparticle preparation, polymer-drug conjugates, biodegradable implants, tissue engineering scaffolds, surface modification, and controlled drug delivery systems.
Applications
- Drug delivery systems
- Nanoparticle formulation
- Polymer-drug conjugates
- Tissue engineering
- Biodegradable implants
- Surface modification
- Protein conjugation
- Peptide conjugation
- Hydrogel preparation
- Biomaterials research
Features and Benefits
- Biodegradable PLLA backbone
- Semi-crystalline polymer structure
- Reactive primary amine functionality
- Excellent biocompatibility
- Superior mechanical strength
- Slower degradation profile than PDLLA
- Suitable for bioconjugation
- Easy chemical modification
- Available in multiple molecular weights
