Description
General Description
Stearic Acid-PEG-Azide (Stearic Acid-PEG-Nā) is an amphiphilic functional PEG derivative consisting of a stearic acid-derived hydrophobic anchor, a hydrophilic polyethylene glycol (PEG) spacer, and a terminal azide (Nā) functional group.
The C18 stearic acid-derived hydrophobic moiety enables association with lipid membranes, liposomes, micelles, nanoparticles, and other hydrophobic materials. The PEG chain provides a hydrophilic spacer and presents the terminal azide group for subsequent chemical modification.
The azide functionality is widely used in bioorthogonal click chemistry. Stearic Acid-PEG-Nā can react with terminal alkynes through copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) or with strained cyclooctynes such as DBCO and BCN through strain-promoted azide-alkyne cycloaddition (SPAAC).
These reactions enable attachment of peptides, proteins, targeting ligands, fluorescent probes, drugs, and other functional molecules to PEGylated lipid assemblies and nanoparticle surfaces.
Applications
- Azide-alkyne click chemistry
- CuAAC conjugation
- Copper-free SPAAC conjugation
- Liposome functionalization
- Nanoparticle surface modification
- Micelle preparation and functionalization
- Targeting ligand attachment
- Protein and peptide conjugation
- Bioorthogonal labeling
- Targeted drug delivery
- Biomaterials research
Features and Benefits
- C18 stearic acid-derived hydrophobic anchor
- Hydrophilic PEG spacer
- Terminal azide (Nā) functionality
- Compatible with CuAAC click chemistry
- Compatible with copper-free SPAAC
- Reactive with alkyne, DBCO, and BCN groups
- Suitable for lipid and nanoparticle functionalization
- Tunable PEG molecular weight
- Custom compositions available
