Description
General Description
DSG-PEG-N₃ is an amphiphilic PEG-lipid designed for lipid nanoparticle (LNP) formulation and bioorthogonal conjugation applications. The hydrophobic DSG moiety contains two C18 stearyl chains that provide strong membrane anchoring and prolonged retention within lipid bilayers compared with shorter-chain PEG lipids.
The PEG chain provides steric stabilization, improved colloidal stability, and reduced nonspecific protein adsorption. The terminal azide group enables highly efficient click chemistry reactions with alkyne- and DBCO-containing molecules through CuAAC and SPAAC chemistry.
DSG-PEG-N₃ is particularly useful for long-circulating liposomes, stable lipid nanoparticles, targeted drug delivery systems, molecular imaging probes, and surface-functionalized nanocarriers where prolonged lipid retention is desired.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) formulation
- Click chemistry conjugation
- Targeted drug delivery
- Molecular imaging
- Antibody conjugation
- Peptide conjugation
- Surface functionalization
- Nanoparticle engineering
- Nanomedicine research
Features and Benefits
- Reactive azide functionality
- Compatible with CuAAC and SPAAC chemistry
- DSG lipid anchor
- Strong membrane retention
- Hydrophilic PEG spacer
- Excellent nanoparticle stabilization
- Reduced protein adsorption
- Suitable for long-circulating formulations
- Available in multiple PEG molecular weights
