Description
General Description
DSG-PEG-Amine is an amphiphilic functional PEG-lipid designed for the preparation of surface-functionalized lipid-based delivery systems. The DSG moiety contains two saturated stearoyl (C18:0) lipid chains that readily incorporate into lipid bilayers, providing excellent membrane stability. The PEG spacer extends into the aqueous phase, enhancing colloidal stability, minimizing nonspecific protein adsorption, and prolonging systemic circulation.
The terminal primary amine readily reacts with activated carboxylic acids (NHS esters), aldehydes, epoxides, isocyanates, and other electrophilic functional groups to form stable covalent linkages. This versatile functionality enables efficient conjugation of antibodies, peptides, proteins, fluorescent dyes, targeting ligands, polymers, and imaging probes to the surface of liposomes and lipid nanoparticles.
DSG-PEG-NH₂ is extensively used in targeted liposome formulation, lipid nanoparticle (LNP) surface engineering, molecular imaging, vaccine development, diagnostic applications, and nanomedicine research.
Applications
- Targeted liposome formulation
- Lipid nanoparticle (LNP) functionalization
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Fluorescent labeling
- Surface modification
- Targeted drug delivery
- Molecular imaging
- Biomaterials research
Features and Benefits
- Amphiphilic functional PEG-lipid
- Stable DSG lipid anchor
- Terminal primary amine functionality
- Versatile conjugation chemistry
- Excellent membrane incorporation
- Improves nanoparticle stability and circulation
- Excellent biocompatibility
- Available in multiple PEG molecular weight
