Description
General Description
DSG-PEG-Maleimide is an amphiphilic functional PEG-lipid designed for the preparation of targeted lipid-based delivery systems. The DSG moiety contains two saturated stearoyl (C18:0) lipid chains that readily incorporate into lipid bilayers, providing excellent membrane stability. The PEG spacer extends into the aqueous phase, enhancing colloidal stability, reducing nonspecific protein adsorption, and prolonging systemic circulation.
The terminal maleimide group reacts rapidly and selectively with free sulfhydryl (thiol) groups on cysteine-containing peptides, proteins, antibodies, enzymes, aptamers, and other thiolated ligands under mild conditions (typically pH 6.5–7.5), forming stable thioether bonds. This chemistry enables efficient surface functionalization of liposomes and lipid nanoparticles for targeted drug and nucleic acid delivery.
DSG-PEG-MAL is extensively used in targeted liposome formulation, lipid nanoparticle (LNP) surface engineering, antibody conjugation, molecular imaging, vaccine development, and nanomedicine research.
Applications
- Targeted liposome formulation
- Lipid nanoparticle (LNP) functionalization
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Thiol-selective surface modification
- Targeted drug delivery
- mRNA delivery
- Molecular imaging
- Biomaterials research
Features and Benefits
- Amphiphilic functional PEG-lipid
- Stable DSG lipid anchor
- Terminal maleimide functionality
- Rapid thiol-selective conjugation
- Stable thioether bond formation
- Excellent membrane incorporation
- Improves nanoparticle stability and circulation
- Available in multiple PEG molecular weights
