DSPE-PEG-OH structure

DSPE-PEG-OH

Price range: $220.00 through $1,100.00

DSPE-PEG-OH is a hydroxyl-functionalized phospholipid-PEG conjugate consisting of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) linked to polyethylene glycol (PEG) and terminated with a hydroxyl group. The amphiphilic structure enables efficient incorporation into liposomes and lipid nanoparticles while providing a reactive hydroxyl functionality for further modification. DSPE-PEG-OH is widely used in liposome formulation, lipid nanoparticle development, drug delivery, and biomaterials research.

Product Specifications

Product Name: DSPE-PEG-OH
CAS No: 
Molecular Weight: 1k, 2k, 3.4k, 5k, 10k Da
Appearance: White to off-white solid
Solubility: Water, Methanol, Chloroform, DMSO
Storage: -20°C, dry and protected from light

DSPE-PEG-OH structure

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SKU: 9609 Categories: , ,

Description

General Description

DSPE-PEG-OH is a versatile lipid-PEG conjugate designed for membrane anchoring and nanoparticle stabilization. The DSPE lipid anchor readily incorporates into liposomal membranes and lipid nanoparticle formulations, while the PEG spacer extends into the aqueous environment, improving colloidal stability, reducing nonspecific interactions, and enhancing circulation properties.

The terminal hydroxyl group provides a useful handle for further chemical modification and polymer synthesis. DSPE-PEG-OH is commonly used as a lipid nanoparticle stabilizer, liposome surface modifier, and synthetic intermediate for preparing functionalized DSPE-PEG derivatives. It is widely utilized in drug delivery, nanomedicine, and biomaterials applications.

Applications

  • Liposome formulation
  • Lipid nanoparticle (LNP) development
  • Drug delivery systems
  • Nanoparticle stabilization
  • Surface modification
  • Polymer synthesis
  • Functional lipid preparation
  • Nanomedicine research
  • Biomaterials development
  • Pharmaceutical formulations

Features and Benefits

  • DSPE anchor for membrane incorporation
  • Hydrophilic PEG spacer improves biocompatibility
  • Terminal hydroxyl group for further modification
  • Improves nanoparticle stability
  • Reduces nonspecific interactions
  • Suitable for liposomes and LNPs
  • Excellent membrane compatibility
  • Useful synthetic intermediate

Additional information

Molecular weight

1000, 2000, 3400, 5000
Package size

100mg, 500mg, 1g

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