Description
General Description
Stearic Acid-PEG-Carboxylic Acid (SA-PEG-COOH) is a heterobifunctional lipid-PEG derivative composed of stearic acid (C18:0), a polyethylene glycol (PEG) spacer, and a terminal carboxylic acid group. The hydrophobic stearic acid moiety readily incorporates into lipid bilayers, liposomes, micelles, and lipid nanoparticles, while the PEG chain improves aqueous solubility, steric stabilization, prolonged circulation time, and biocompatibility.
The terminal carboxyl group provides a versatile reactive site that can be activated using carbodiimide coupling reagents such as EDC/NHS to react with primary amines on proteins, peptides, antibodies, enzymes, polymers, and other biomolecules, forming stable amide bonds. The free carboxyl group also enables electrostatic interactions and further chemical modifications.
Stearic Acid-PEG-Carboxylic Acid is widely employed for preparing functional liposomes, lipid nanoparticles (LNPs), targeted drug delivery systems, surface modification, hydrogel fabrication, molecular imaging, biosensors, and advanced biomaterials.
Applications
- Liposome surface modification
- Lipid nanoparticle (LNP) functionalization
- Biomolecule conjugation
- Protein conjugation
- Peptide conjugation
- Antibody conjugation
- Targeted drug delivery
- Nanoparticle surface engineering
- Molecular imaging
- Biomaterials research
Features and Benefits
- Hydrophobic stearic acid anchor
- Hydrophilic PEG spacer
- Terminal carboxylic acid functionality
- Compatible with EDC/NHS coupling chemistry
- Stable amide bond formation
- Excellent aqueous dispersibility
- Outstanding biocompatibility
- Research-grade quality
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