MPEG-PLGA-COOH structure

mPEG-PLGA-COOH

Price range: $200.00 through $600.00

MPEG-PLGA-COOH is a biodegradable diblock copolymer composed of methoxy polyethylene glycol (MPEG) and poly(D,L-lactide-co-glycolide) (PLGA) terminated with a carboxylic acid group. The polymer combines the hydrophilicity of MPEG with the biodegradability of PLGA while providing a reactive carboxyl group for conjugation to peptides, proteins, antibodies, and other biomolecules. MPEG-PLGA-COOH is widely used in nanoparticle formulation, drug delivery, and biomaterials research.

Product Name: MPEG-PLGA-COOH
Polymer Composition: Methoxy Polyethylene Glycol-block-Poly(D,L-lactide-co-glycolic acid)-Carboxylic Acid
Molecular Weight: Various MPEG and PLGA molecular weights available
Lactide:Glycolide Ratio: 50:50, 65:35, 75:25, 85:15, Custom
Functional Groups: MPEG, PLGA, Carboxylic Acid (COOH)
Appearance: White to off-white solid
Solubility: Water, DMSO, DMF, Acetone, THF, Dichloromethane, Chloroform
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

MPEG-PLGA-COOH structure

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SKU: 9780 Categories: , ,

Description

General Description

MPEG-PLGA-COOH is an amphiphilic block copolymer consisting of a hydrophilic MPEG segment and a biodegradable PLGA segment terminated with a carboxylic acid group. The MPEG block improves aqueous stability and biocompatibility, while the PLGA block enables controlled biodegradation and hydrophobic drug encapsulation.

The terminal carboxyl group provides a versatile reactive site for conjugation through carbodiimide (EDC/NHS) chemistry and other carboxyl-coupling reactions. MPEG-PLGA-COOH readily self-assembles into polymeric micelles and nanoparticles in aqueous environments and is widely used for targeted drug delivery, nanoparticle surface functionalization, imaging probe preparation, and advanced biomaterials development.

Applications

  • Polymeric nanoparticle preparation
  • Drug delivery systems
  • Controlled drug release
  • Targeted drug delivery
  • Peptide conjugation
  • Protein conjugation
  • Antibody conjugation
  • Surface modification
  • Nanomedicine research
  • Biomaterials development

Features and Benefits

    • Biodegradable PLGA segment
    • Hydrophilic MPEG segment
    • Reactive carboxylic acid functionality
    • Compatible with EDC/NHS coupling chemistry
    • Self-assembles into nanoparticles and micelles
    • Excellent biocompatibility
    • Suitable for hydrophobic drug encapsulation
    • Controlled degradation profile
    • Available in multiple MPEG and PLGA molecular weights

Additional information

PLGA Molecular Weight

2K, 5K, 10K
PEG Molecular Weight

1K, 2K, 5K
Package Size

100mg, 1g

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