Description
General Description
PLGA Acid Capped (85:15) is a carboxyl-terminated biodegradable polyester composed of 85% lactide and 15% glycolide. Compared with PLGA 50:50 and 75:25, the higher lactide content increases hydrophobicity and significantly slows polymer degradation, making this composition particularly suitable for long-term drug release and implantable biomedical applications.
The terminal carboxylic acid group provides a versatile reactive handle for conjugation with polyethylene glycol (PEG), peptides, proteins, antibodies, fluorophores, and targeting ligands using carbodiimide (EDC/NHS) coupling chemistry. As a result, PLGA-COOH (85:15) is widely used as a precursor for functional PLGA derivatives and targeted drug delivery systems.
PLGA Acid Capped (85:15) is extensively employed in nanoparticles, microspheres, injectable depots, implantable devices, tissue engineering scaffolds, and controlled-release formulations requiring prolonged degradation profiles.
Applications
- Sustained drug delivery
- Long-acting injectable formulations
- Nanoparticle formulation
- Microsphere preparation
- Implantable drug delivery systems
- PEG conjugation
- Protein conjugation
- Tissue engineering
- Biomaterials development
- Biomedical research
Features and Benefits
- Terminal carboxylic acid functionality
- 85:15 lactide composition
- Slower degradation profile
- Extended drug release
- Compatible with EDC/NHS coupling chemistry
- Excellent biocompatibility
- Excellent drug encapsulation capability
- Available in multiple molecular weights
- Ideal precursor for PLGA conjugates
