Description
General Description
PLGA-PEG-SH is a functional biodegradable copolymer designed for nanoparticle engineering and thiol-mediated conjugation applications. The hydrophobic PLGA segment forms the core of nanoparticles and micelles capable of encapsulating hydrophobic drugs, proteins, peptides, and imaging agents, while the PEG segment forms a hydrophilic corona that enhances colloidal stability and reduces nonspecific protein adsorption.
The terminal thiol group readily reacts with maleimides, vinyl sulfones, activated disulfides, and acrylates, enabling efficient attachment of antibodies, peptides, proteins, fluorophores, nanoparticles, and targeting ligands. PLGA-PEG-SH combines the biodegradability of PLGA with the versatility of thiol chemistry, making it useful for targeted drug delivery systems, polymer therapeutics, imaging agents, and advanced biomaterials.
Applications
- Drug delivery systems
- Nanoparticle formulation
- Polymeric micelle preparation
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface modification
- Tissue engineering
- Nanomedicine research
Features and Benefits
- Biodegradable PLGA segment
- Hydrophilic PEG spacer
- Reactive thiol functionality
- Suitable for thiol-specific conjugation
- Excellent biocompatibility
- Improves nanoparticle stability
- Reduces protein adsorption
- Supports controlled drug release
- Available in multiple molecular weights
