PLL-g-PEG structure

PLL-g-PEG

Price range: $280.00 through $460.00

PLL-g-PEG is a graft copolymer composed of poly(L-lysine) (PLL) and polyethylene glycol (PEG). The PEG chains improve the biocompatibility, water solubility, and antifouling properties of PLL while retaining the cationic characteristics of lysine residues. PLL-g-PEG is widely used for surface modification, cell culture substrates, biomaterials engineering, drug delivery, and biomedical research.

Product Specifications

Product Name: PLL-g-PEG
Polymer Composition: Poly(L-lysine)-graft-Polyethylene Glycol
Molecular Weight: Various PLL and PEG molecular weights, and PEG substitution degree available
Functional Groups: Poly(L-lysine), PEG
Appearance: White to off-white solid
Solubility: Water, PBS, Aqueous Buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PLL-g-PEG structure

# of repeating units of PLL        PLL MW                             PEG substitution degree  (dPEG)                                g    =    1/dPEG
20                                                             2.6K                                                  10%                                                                               10
50                                                              6.7k                                                  20%                                                                               5
100                                                           13K                                                    30%                                                                              3.3
150                                                           20k
200                                                           26K

PLL150-g(30%)-2000   is equivalent to PLL(20K)-g(3.3)-PEG2K or briefly PLL20-g(3.3)-PEG2

 

SKU: 11354 Categories: , ,

Description

General Description

PLL-g-PEG is synthesized by grafting polyethylene glycol chains onto a poly(L-lysine) backbone. The PLL component provides multiple primary amine groups and strong electrostatic interactions with negatively charged surfaces and biomolecules, while PEG improves hydrophilicity, biocompatibility, and resistance to nonspecific protein adsorption.

PLL-g-PEG has become a widely used surface-coating material for biomedical and biotechnology applications. The grafted PEG chains create a steric barrier that minimizes nonspecific adsorption of proteins and cells while maintaining the ability of PLL to adsorb onto negatively charged substrates. PLL-g-PEG is frequently used in biosensors, microfluidic devices, tissue engineering, cell culture platforms, and surface passivation applications.

Applications

  • Surface modification
  • Antifouling coatings
  • Cell culture substrates
  • Biosensor development
  • Microfluidic device coatings
  • Biomolecule immobilization
  • Tissue engineering
  • Drug delivery research
  • Biomedical device coatings
  • Biomaterials research

Features and Benefits

  • Graft copolymer architecture
  • Poly(L-lysine) backbone for surface adsorption
  • Hydrophilic PEG chains reduce nonspecific binding
  • Excellent biocompatibility
  • Improves surface passivation
  • Reduces protein adsorption
  • Suitable for cell culture applications
  • Compatible with biological systems
  • Available in various PLL and PEG molecular weights

 

Additional information

Number of repeating units (PLL)

20, 50, 100, 150, 200
Molecular weight of PEG

2000, 5000
Percentage of PEG substitution

10%, 20%, 30%
Package size

50mg, 100mg

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