PLL-g-PEG structure

PLL-g-PEG

Price range: $280.00 through $460.00

PLL-g-PEG is a graft copolymer composed of poly(L-lysine) (PLL) and polyethylene glycol (PEG). The PEG chains improve the biocompatibility, water solubility, and antifouling properties of PLL while retaining the cationic characteristics of lysine residues. PLL-g-PEG is widely used for surface modification, cell culture substrates, biomaterials engineering, drug delivery, and biomedical research.

Product Specifications

Product Name: PLL-g-PEG
Polymer Composition: Poly(L-lysine)-graft-Polyethylene Glycol
Molecular Weight: Various PLL and PEG molecular weights, and PEG substitution degree available
Functional Groups: Poly(L-lysine), PEG
Appearance: White to off-white solid
Solubility: Water, PBS, Aqueous Buffers
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

PLL-g-PEG structure

# of repeating units of PLL        PLL MW                             PEG substitution degree  (dPEG)                                g    =    1/dPEG
20                                                             2.6K                                                  10%                                                                               10
50                                                              6.7k                                                  20%                                                                               5
100                                                           13K                                                    30%                                                                              3.3
150                                                           20k
200                                                           26K

PLL150-g(30%)-2000   is equivalent to PLL(20K)-g(3.3)-PEG2K or briefly PLL20-g(3.3)-PEG2

 

SKU: 11354 Categories: , ,

Description

General Description

PLL-g-PEG is synthesized by grafting polyethylene glycol chains onto a poly(L-lysine) backbone. The PLL component provides multiple primary amine groups and strong electrostatic interactions with negatively charged surfaces and biomolecules, while PEG improves hydrophilicity, biocompatibility, and resistance to nonspecific protein adsorption.

PLL-g-PEG has become a widely used surface-coating material for biomedical and biotechnology applications. The grafted PEG chains create a steric barrier that minimizes nonspecific adsorption of proteins and cells while maintaining the ability of PLL to adsorb onto negatively charged substrates. PLL-g-PEG is frequently used in biosensors, microfluidic devices, tissue engineering, cell culture platforms, and surface passivation applications.

Applications

  • Surface modification
  • Antifouling coatings
  • Cell culture substrates
  • Biosensor development
  • Microfluidic device coatings
  • Biomolecule immobilization
  • Tissue engineering
  • Drug delivery research
  • Biomedical device coatings
  • Biomaterials research

Features and Benefits

  • Graft copolymer architecture
  • Poly(L-lysine) backbone for surface adsorption
  • Hydrophilic PEG chains reduce nonspecific binding
  • Excellent biocompatibility
  • Improves surface passivation
  • Reduces protein adsorption
  • Suitable for cell culture applications
  • Compatible with biological systems
  • Available in various PLL and PEG molecular weights

 

Additional information

PLL repeating units

20, 50, 100, 150, 200
Molecular weight of PEG

2000, 5000
Percentage of PEG substitution

10%, 20%, 30%
Package size

50mg, 100mg

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