Description
General Description
Cholesterol-PEG-Folate is a targeted lipid-PEG conjugate designed for membrane anchoring and folate receptor-mediated delivery. The cholesterol segment readily inserts into liposomal membranes and lipid nanoparticle formulations, while the PEG spacer extends into the aqueous environment, improving colloidal stability, circulation properties, and reducing nonspecific interactions.
The terminal folate ligand specifically recognizes folate receptors that are overexpressed on many cancer cells and activated macrophages. This targeting capability enables enhanced cellular uptake and selective delivery of therapeutics, imaging agents, and nanomedicines. Cholesterol-PEG-Folate is widely used in targeted liposomes, lipid nanoparticles, drug delivery systems, diagnostic applications, and cancer research.
Applications
- Liposome formulation
- Lipid nanoparticle (LNP) development
- Targeted drug delivery
- Folate receptor targeting
- Cancer-targeting nanoparticles
- Molecular imaging
- Diagnostic applications
- Surface modification
- Nanomedicine research
- Biomolecule delivery
Features and Benefits
- Cholesterol anchor for membrane incorporation
- Hydrophilic PEG spacer improves biocompatibility
- Folate ligand enables receptor-mediated targeting
- Enhances cellular uptake in folate receptor-positive cells
- Improves nanoparticle stability
- Reduces nonspecific interactions
- Suitable for liposomes and LNPs
- Compatible with targeted drug delivery systems
- Available in multiple PEG molecular weights
