DSPE-Hydrazone-mPEG

Description

General Description

DSPE-Hydrazone-mPEG is a pH-sensitive phospholipid–poly(ethylene glycol) conjugate containing DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine, C18:0), a PEG spacer, and an acid-labile hydrazone linker. The hydrazone bond remains relatively stable under physiological conditions but undergoes cleavage under acidic environments such as tumor tissues, endosomes, and lysosomes.

Key Properties

• pH-sensitive PEG lipid conjugate
• Acid-labile hydrazone linkage
• Stimuli-responsive lipid material
• DSPE phospholipid anchor (C18:0)
• PEG spacer improves circulation stability and biocompatibility

Applications

• Stimuli-responsive drug delivery
• pH-sensitive liposomes and LNP systems
• Tumor-targeted nanomedicine
• Endosomal release systems
• Controlled payload release
• Advanced biomaterial engineering

Functional Overview

The DSPE lipid segment incorporates into lipid bilayers, while the PEG chain provides steric stabilization and prolonged circulation. Under acidic conditions, the hydrazone linker undergoes cleavage, enabling triggered PEG shedding or controlled release behavior.

Summary

DSPE-Hydrazone-mPEG is a versatile pH-sensitive PEG phospholipid widely used in stimuli-responsive liposomes, lipid nanoparticle engineering, and advanced drug delivery applications.