Description
General Description
PCL-Biotin (PCL-Bio) is a biotin-functionalized poly(ε-caprolactone) in which a PCL polymer chain is functionalized with a terminal biotin group.
Poly(ε-caprolactone) (PCL) is a hydrophobic, biodegradable aliphatic polyester widely used in polymeric nanoparticles, biomaterials, controlled-release systems, and drug delivery research.
The terminal biotin group provides strong noncovalent binding to avidin, streptavidin, and neutravidin. This affinity interaction enables Biotin-PCL-containing materials to interact with streptavidin-functionalized proteins, probes, surfaces, nanoparticles, and other biomolecular systems.
Biotin-PCL can be incorporated into polymeric nanoparticles or other PCL-based materials to introduce biotin functionality while maintaining the biodegradable PCL component.
Applications
- Biotin-functionalized nanoparticles
- Polymeric nanoparticle preparation
- Affinity-based immobilization
- Streptavidin-mediated conjugation
- Biomaterials research
- Drug delivery research
- Surface functionalization
- Polymer-bioconjugate preparation
- Affinity capture systems
- Functional biodegradable materials
Features and Benefits
- Terminal biotin functionality
- Biodegradable PCL backbone
- Strong biotin–streptavidin interaction
- Hydrophobic polyester segment
- Suitable for nanoparticle formulation
- Useful for affinity-based conjugation
- Suitable for functional biomaterial development
- Multiple molecular weights available
- Custom molecular weights available
