PDLLA-MPEG

Description

General Description

PDLLA-mPEG, also referred to as mPEG-PDLLA, is a biodegradable amphiphilic block copolymer consisting of a hydrophilic methoxy polyethylene glycol (mPEG) block and a hydrophobic poly(D,L-lactide) (PDLLA) block.

PDLLA is an amorphous biodegradable polyester derived from D,L-lactide. In combination with hydrophilic PEG, the resulting block copolymer can exhibit amphiphilic behavior and self-assemble into micelles, nanoparticles, and other nanoscale structures under appropriate formulation conditions.

The hydrophobic PDLLA domain can associate with hydrophobic compounds, while the PEG segment forms a hydrophilic corona that can improve colloidal stability in aqueous environments.

NSP offers PDLLA-mPEG with different PDLLA and mPEG molecular weights to support formulation development, nanoparticle research, drug delivery, and biomaterials applications.

Applications

• Polymeric nanoparticle preparation
• Polymeric micelle formation
• Drug delivery research
• Hydrophobic drug encapsulation
• Controlled-release formulations
• Nanomedicine research
• Biodegradable biomaterials
• Amphiphilic block copolymer research
• Polymer self-assembly
• Formulation development

Features and Benefits

• Amphiphilic diblock copolymer
• Biodegradable PDLLA block
• Hydrophilic mPEG block
• Hydrophobic PDLLA domain
• Suitable for micelle and nanoparticle formation
• Useful for hydrophobic compound encapsulation
• Amorphous PDLLA segment
• Multiple block molecular weights available
• Custom PDLLA/mPEG compositions available