Description
General Description
2-(2-Pyridyldithio)ethylamine Hydrochloride is a versatile heterobifunctional coupling reagent designed for the preparation of thiol-reactive biomolecules and polymers. The molecule contains a primary amine and a 2-pyridyl disulfide (PDP) moiety, providing two orthogonal reactive functionalities.
The primary amine readily reacts with activated carboxylic acids, NHS esters, isocyanates, and aldehydes to form stable covalent linkages. The pyridyl disulfide group selectively reacts with sulfhydryl-containing molecules through thiol-disulfide exchange, releasing pyridine-2-thione and generating reversible disulfide bonds.
Because the resulting disulfide linkage can be cleaved under intracellular reducing conditions, 2-(2-Pyridyldithio)ethylamine Hydrochloride is widely employed in the preparation of redox-responsive drug conjugates, PEG derivatives, antibody conjugates, protein conjugates, polymer therapeutics, nanoparticles, and advanced biomaterials.
Applications
- PEG synthesis
- Protein conjugation
- Antibody modification
- Peptide conjugation
- Thiol-selective bioconjugation
- Drug delivery systems
- Redox-responsive linkers
- Nanoparticle functionalization
- Surface modification
- Biomaterials research
Features and Benefits
- Heterobifunctional linker
- Primary amine functionality
- Thiol-reactive pyridyl disulfide group
- Orthogonal conjugation chemistry
- Cleavable disulfide linkage
- Compatible with NHS ester chemistry
- High coupling efficiency
- Research-grade quality
