Description
General Description
8-arm PEG-SAS is a branched PEG macromolecule functionalized with succinic acid succinimidyl ester (SAS) groups at the terminus of each PEG arm. The activated NHS ester groups readily react with primary amines under mild aqueous conditions (typically pH 7.2–8.5), producing stable amide linkages while preserving the biological activity of sensitive biomolecules.
The eight-arm architecture provides a high density of reactive sites, allowing efficient multivalent conjugation and rapid hydrogel crosslinking. Compared with linear PEG derivatives, 8-arm PEG-SAS offers higher crosslinking efficiency, enhanced mechanical strength, and improved control over three-dimensional PEG network formation.
8-arm PEG-SAS is widely used in protein PEGylation, antibody conjugation, enzyme immobilization, hydrogel fabrication, cell encapsulation, tissue engineering, regenerative medicine, controlled drug delivery, and surface functionalization.
Applications
- PEG hydrogel synthesis
- Hydrogel crosslinking
- Protein PEGylation
- Antibody conjugation
- Enzyme immobilization
- Cell encapsulation
- Tissue engineering
- Regenerative medicine
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Eight-arm PEG architecture
- Terminal succinic acid succinimidyl ester (SAS) groups
- Highly reactive toward primary amines
- Stable amide bond formation
- High crosslinking efficiency
- Excellent water solubility
- Outstanding biocompatibility
- Research-grade quality
