ALC-0315 ionizable lipid structure

ALC-0315

Price range: $260.00 through $1,600.00

ALC-0315 is a biodegradable ionizable lipid widely used in lipid nanoparticle (LNP) formulations for mRNA delivery. As a key lipid component in the Pfizer-BioNTech COVID-19 mRNA vaccine, ALC-0315 enables efficient encapsulation, intracellular delivery, and endosomal escape of mRNA therapeutics. It is extensively used in mRNA delivery, gene therapy, vaccine development, and lipid nanoparticle research.

Product Name: ALC-0315
Chemical Name: (4-Hydroxybutyl)azanediyl bis(hexane-6,1-diyl) bis(2-hexyldecanoate)
CAS Number: 2036272-55-4
Molecular Formula: C48H95NO5
Molecular Weight: 766.3 Da
Lipid Type: Ionizable Lipid
Appearance: Colorless to pale yellow oil or waxy solid
Purity: Typically ≥95%
Solubility: Ethanol, Chloroform, Methanol
Storage: -20°C, protected from moisture and light

ALC-0315 ionizable lipid structure

 

Request Bulk Quote? Request Custom Synthesis?
SKU: 28068 Categories: ,

Product Details

Name: ALC-0315

CAS#: 2036272-55-4

Chemical Formula: C48H95NO5

Exact Mass: 765.7210

Molecular Weight: 766.29

Elemental Analysis: C, 75.24; H, 12.50; N, 1.83; O, 10.44

Purity: 98%

COA

2806807

Description

General Description

ALC-0315 is an ionizable amino lipid specifically designed for nucleic acid delivery applications. During LNP formulation at acidic pH, ALC-0315 becomes positively charged, facilitating efficient complexation and encapsulation of negatively charged mRNA molecules. Under physiological conditions, the lipid remains largely neutral, minimizing toxicity and improving biocompatibility.

Following cellular uptake, the acidic endosomal environment protonates the ionizable amine groups, promoting endosomal membrane disruption and efficient release of mRNA into the cytoplasm. This mechanism contributes significantly to the high transfection efficiency observed in mRNA-LNP systems.

ALC-0315 has become one of the most important ionizable lipids in modern mRNA therapeutics and serves as a benchmark lipid for the development of next-generation lipid nanoparticle delivery systems.

Applications

  • mRNA delivery
  • Lipid nanoparticle (LNP) formulation
  • Vaccine development
  • Gene therapy
  • RNA therapeutics
  • CRISPR delivery
  • Protein expression studies
  • Drug delivery systems
  • Nanomedicine research
  • Nucleic acid delivery

Features and Benefits

  • Biodegradable ionizable lipid
  • Efficient mRNA encapsulation
  • Promotes endosomal escape
  • High transfection efficiency
  • Reduced systemic toxicity
  • Optimized for LNP formulation
  • Widely validated in mRNA delivery
  • Suitable for large-scale manufacturing
  • Benchmark lipid for mRNA therapeutics

Additional information

Package size

50mg, 100mg, 200mg, 500mg, 1g

Related products