Description
General Description
DSPE-N3 is a click-reactive lipid designed for post-functionalization of lipid-based delivery systems. The DSPE lipid anchor consists of two saturated stearoyl (C18:0) hydrocarbon chains that provide strong hydrophobic interaction and stable incorporation into lipid bilayers, liposomes, and lipid nanoparticles.
The terminal azide group enables highly selective click chemistry, including copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN. These reactions allow efficient attachment of targeting ligands, peptides, antibodies, polymers, fluorescent probes, and other functional molecules.
DSPE-N3 combines excellent membrane anchoring ability with bioorthogonal azide chemistry, making it a valuable lipid building block for targeted nanoparticles, functional liposomes, imaging agents, and advanced nanomedicine applications.
Applications
- Click chemistry (CuAAC)
- Copper-free click chemistry (SPAAC)
- Liposome functionalization
- Lipid nanoparticle (LNP) modification
- Antibody attachment
- Peptide conjugation
- Targeted drug delivery
- Molecular imaging
- Biosensor fabrication
- Biomaterials research
Features and Benefits
- Reactive azide functionality
- Stable DSPE lipid anchor
- Compatible with CuAAC and SPAAC reactions
- Efficient membrane incorporation
- Suitable for liposomes and LNPs
- Enables bioorthogonal modification
- Useful for targeted delivery applications
- Biocompatible lipid material
