Description
General Description
Folate-PEG-Amine is a multifunctional PEG linker designed for receptor-mediated targeting and bioconjugation applications. Folic acid exhibits high affinity for folate receptors, which are overexpressed on numerous cancer cells including ovarian, breast, lung, kidney, colorectal, and cervical cancers. This receptor-mediated uptake pathway makes folate one of the most widely used targeting ligands in nanomedicine and drug delivery.
The hydrophilic PEG spacer improves aqueous solubility, biocompatibility, flexibility, and reduces nonspecific interactions. The terminal primary amine group serves as a versatile handle for conjugation with NHS esters, activated carboxylic acids, aldehydes, fluorophores, polymers, nanoparticles, proteins, peptides, antibodies, and imaging agents.
Folate-PEG-Amine is frequently employed in targeted nanoparticle development, liposome functionalization, imaging probe preparation, molecular diagnostics, and cancer-targeted therapeutics.
Applications
- Targeted drug delivery
- Cancer-targeting nanoparticles
- Liposome functionalization
- Antibody conjugation
- Peptide conjugation
- Imaging probe preparation
- Molecular diagnostics
- Surface modification
- Biomaterials development
- Nanomedicine research
Features and Benefits
- Folate receptor targeting ligand
- Reactive primary amine functionality
- Receptor-mediated cellular uptake
- Hydrophilic PEG spacer
- Excellent water solubility
- Improved biocompatibility
- Reduced nonspecific adsorption
- Suitable for nanoparticle functionalization
- Available in multiple PEG molecular weights
