Description
General Description
mPEG-Tosylate is a highly versatile monofunctional PEG intermediate designed for the preparation of a broad range of functional PEG reagents. The terminal methoxy group is chemically inert, preventing polymer crosslinking, while the tosylate group serves as an excellent leaving group for nucleophilic substitution (SN2) reactions.
The tosylate functionality readily reacts with primary and secondary amines, thiols, alkoxides, azide ions, cyanide, and numerous other nucleophiles, enabling efficient synthesis of amino-, thiol-, azide-, alkyne-, and other functional PEG derivatives. Due to its excellent stability during storage and high synthetic versatility, mPEG-Tosylate is one of the most commonly used PEG intermediates in organic synthesis.
The PEG spacer improves aqueous solubility, enhances biocompatibility, and provides flexibility between the polymer backbone and newly introduced functional groups. mPEG-Tosylate is extensively employed in polymer synthesis, drug delivery, nanoparticle engineering, surface modification, and biomaterials research.
Applications
- PEG intermediate synthesis
- Functional PEG preparation
- Nucleophilic substitution reactions
- Azide PEG synthesis
- Amine PEG synthesis
- Thiol PEG synthesis
- Polymer modification
- Drug delivery research
- Nanoparticle functionalization
- Biomaterials research
Features and Benefits
- Monofunctional PEG intermediate
- Highly reactive tosylate leaving group
- Efficient SN2 substitution chemistry
- Excellent synthetic versatility
- Excellent water solubility
- Excellent biocompatibility
- Stable during storage
- Available in multiple PEG molecular weights
Product Specifications
Product Name: mPEG-Tosylate
Alternative Name: Methoxy PEG Tosylate, MPEG-OTs, mPEG-OTs
Molecular Weight: 350, 550, 750, 1000, 2000, 5000, 10000, 20000 Da, Custom
Functional Groups: Methoxy PEG, Tosylate (p-Toluenesulfonate)
Appearance: White to off-white solid
Solubility: Water, methanol, ethanol, DMSO, DMF
Storage: -20°C, dry, moisture-free, and protected from light
Purity: Typically ≥95%
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