Description
General Description
4-Arm PEG-SH is a branched PEG derivative designed for thiol-mediated crosslinking and bioconjugation applications. Compared with linear PEG derivatives, the four-arm architecture provides higher functional group density, enhanced crosslinking efficiency, and improved network formation.
The terminal thiol groups readily react with maleimides, vinyl sulfones, acrylates, methacrylates, and activated disulfides under mild conditions to form stable covalent linkages. Thiol-based chemistry is widely utilized in hydrogel fabrication, protein immobilization, cell encapsulation, controlled drug delivery, and tissue engineering applications.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and resistance to nonspecific protein adsorption. 4-Arm PEG-SH is frequently employed in injectable hydrogels, regenerative medicine, nanoparticle functionalization, and advanced biomaterials development.
Applications
- Hydrogel synthesis
- Injectable hydrogels
- Tissue engineering
- Cell encapsulation
- Drug delivery systems
- Protein conjugation
- Peptide conjugation
- Surface modification
- Nanoparticle functionalization
- Biomaterials research
Features and Benefits
- Four terminal thiol groups
- Multi-arm PEG architecture
- Efficient thiol-based conjugation
- High crosslinking efficiency
- Compatible with maleimide chemistry
- Excellent water solubility
- Excellent biocompatibility
- Low protein adsorption
- Available in multiple molecular weights
