Description
General Description
OPSS-Poly(L-Glutamic Acid) is a functional polypeptide designed for reversible bioconjugation and advanced drug delivery applications. The terminal OPSS (ortho-pyridyl disulfide) group reacts rapidly and selectively with free sulfhydryl (thiol) groups on proteins, peptides, antibodies, and other biomolecules through thiol-disulfide exchange, forming cleavable disulfide linkages while releasing pyridine-2-thione.
The biodegradable poly(L-glutamic acid) backbone contains numerous pendant carboxylic acid groups that can be activated using EDC/NHS chemistry or peptide-coupling reagents for conjugation with proteins, peptides, antibodies, drugs, polymers, nanoparticles, and imaging agents.
The combination of a biodegradable polymer backbone, multiple reactive carboxyl groups, and a terminal OPSS functionality makes OPSS-pGlu an excellent material for redox-responsive drug delivery, polymer-drug conjugates, reversible protein conjugation, hydrogel synthesis, nanoparticle functionalization, and advanced biomaterials.
Applications
- Reversible thiol conjugation
- Drug conjugation
- Polymer-drug conjugates
- Protein and antibody conjugation
- Nanoparticle functionalization
- Hydrogel synthesis
- Surface modification
- Redox-responsive drug delivery
- Molecular imaging
- Biomaterials research
Features and Benefits
- Terminal OPSS functionality
- Selective thiol-disulfide exchange
- Forms cleavable disulfide linkages
- Biodegradable poly(L-glutamic acid) backbone
- Multiple pendant carboxylic acid groups
- Compatible with EDC/NHS coupling
- Excellent aqueous solubility
- Available in multiple molecular weights
