Description
General Description
8-arm PEG-GAA (8-Arm PEG-amino glutamic acid)  is a multifunctional PEG derivative designed for advanced biomaterials and bioconjugation applications. The eight-arm architecture provides a high density of amino glutamic acid residues at each arm, introducing both primary amine and carboxyl functionalities for flexible chemical modification.
The terminal primary amine groups readily react with NHS esters, aldehydes, epoxides, and activated carboxylic acids, while the carboxyl groups can be activated using EDC/NHS chemistry for coupling to amine-containing biomolecules. This dual-functionality enables orthogonal conjugation strategies and the preparation of highly crosslinked hydrogel networks.
The PEG backbone provides excellent water solubility, flexibility, and biocompatibility while minimizing nonspecific protein adsorption. The multi-arm architecture offers high functional group density, making this polymer ideal for hydrogel fabrication, protein immobilization, nanoparticle engineering, regenerative medicine, and advanced biomaterials development.
Applications
- Hydrogel synthesis
- Protein conjugation
- Antibody conjugation
- Peptide conjugation
- Surface modification
- Nanoparticle functionalization
- Tissue engineering
- Drug delivery systems
- Regenerative medicine
- Biomaterials research
Features and Benefits
- Eight terminal amino glutamic acid groups
- Dual amine and carboxyl functionalities
- High functional group density
- Compatible with EDC/NHS coupling chemistry
- Reactive primary amine groups
- Excellent water solubility
- Excellent biocompatibility
- High crosslinking efficiency
- Suitable for advanced hydrogel fabrication
