Description
General Description
8-Arm PEG-SA is a multifunctional PEG derivative designed for advanced bioconjugation and hydrogel fabrication. The eight-arm architecture provides a high density of terminal succinic acid functionalities, each presenting a free carboxyl group that can be activated for efficient coupling to proteins, peptides, antibodies, enzymes, polymers, and biomaterial surfaces.
Compared with 8-Arm PEG-COOH, the succinic acid spacer introduces an additional flexible linker between the PEG backbone and the terminal carboxyl group, improving accessibility of the reactive carboxyl group while reducing steric hindrance during conjugation.
The PEG backbone provides excellent water solubility, flexibility, biocompatibility, and minimizes nonspecific protein adsorption. The high density of carboxyl groups makes 8-Arm PEG-SA particularly useful for hydrogel fabrication, regenerative medicine, nanoparticle engineering, protein conjugation, and advanced biomaterials development.
Applications
- Hydrogel synthesis
- Protein conjugation
- Antibody conjugation
- Peptide conjugation
- Surface modification
- Nanoparticle functionalization
- Tissue engineering
- Drug delivery systems
- Regenerative medicine
- Biomaterials research
Features and Benefits
- Eight terminal succinic acid groups
- High-density carboxyl functionality
- Compatible with EDC/NHS coupling chemistry
- Flexible succinic acid spacer
- Excellent water solubility
- Excellent biocompatibility
- High crosslinking efficiency
- Low protein adsorption
- Suitable for hydrogel fabrication
