PLGA Ester Capped (75:25)

PLGA Ester Capped (75:25)

Price range: $80.00 through $360.00

PLGA Ester Capped (75:25) is a biodegradable poly(lactide-co-glycolide) copolymer with a 75:25 lactide ratio and an ester-terminated end group. Compared with acid-capped PLGA, ester-capped PLGA exhibits lower hydrophilicity and improved hydrolytic stability, resulting in a slower degradation profile. PLGA Ester Capped (75:25) is widely used in nanoparticle formulation, sustained drug delivery, microsphere preparation, tissue engineering, and biomaterials research.

Product Name: PLGA Ester Capped (75:25)
Alternative Name: Ester-Terminated PLGA (75:25), End-Capped PLGA (75:25)
Polymer Type: Poly(D,L-lactide-co-glycolide)
Lactide Ratio: 75:25
Molecular Weight: 2k, 5k, 10k, 15k, 20k, 30k, 50k, 100k Da, Custom
End Group: Ester
Appearance: White to off-white powder or solid
Solubility: Dichloromethane, Chloroform, THF, Acetone, DMF, DMSO
Storage: -20°C, dry and protected from moisture
Purity: Typically ≥99%

 

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SKU: 43823 Categories: , ,

Description

General Description

PLGA Ester Capped (75:25) is a biodegradable aliphatic polyester composed of 75% lactide and 25% glycolide with an ester end group. The increased lactide content makes the polymer more hydrophobic than PLGA 50:50, resulting in slower hydrolytic degradation and prolonged drug release. The ester-capped terminus further reduces water uptake and minimizes the autocatalytic degradation associated with free carboxyl end groups, enhancing polymer stability during storage and application.

PLGA Ester Capped (75:25) is well suited for sustained-release formulations, biodegradable nanoparticles, microspheres, injectable depots, implantable drug delivery systems, and tissue engineering scaffolds. Its degradation profile can be further tailored by selecting different molecular weights.

Applications

  • Sustained drug delivery
  • Nanoparticle formulation
  • Microsphere preparation
  • Injectable depot systems
  • Controlled-release formulations
  • Tissue engineering
  • Biodegradable implants
  • Vaccine delivery
  • Medical devices
  • Biomaterials research

Features and Benefits

  • Ester-terminated PLGA
  • 75:25 lactide composition
  • Moderate degradation profile
  • Lower hydrophilicity than acid-capped PLGA
  • Improved hydrolytic stability
  • Excellent drug encapsulation capability
  • Excellent biocompatibility
  • Available in multiple molecular weights
  • Suitable for sustained-release formulations

Additional information

Molecular weight

5K, 10K, 20K, 50K, 70K, 100K, 150K, 200k, 300K
Package szie

1g, 5g

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