Description
General Description
PLGA Ester Capped (85:15) is a biodegradable aliphatic polyester composed of 85% lactide and 15% glycolide with an ester end group. The high lactide content increases polymer hydrophobicity and crystallinity relative to lower lactide compositions, resulting in significantly slower hydrolytic degradation and extended release profiles.
Unlike acid-capped PLGA, ester-capped PLGA lacks a free terminal carboxylic acid, reducing water uptake and minimizing autocatalytic degradation. This provides improved storage stability and longer in vivo residence times, making PLGA Ester Capped (85:15) particularly suitable for long-term controlled drug release, implantable formulations, and sustained therapeutic delivery.
PLGA Ester Capped (85:15) is widely used for preparing biodegradable nanoparticles, microspheres, injectable depots, implantable devices, tissue engineering scaffolds, and long-acting pharmaceutical formulations.
Applications
- Long-acting drug delivery
- Sustained-release formulations
- Nanoparticle formulation
- Microsphere preparation
- Injectable depot systems
- Implantable drug delivery
- Tissue engineering
- Biodegradable medical devices
- Vaccine delivery
- Biomaterials research
Features and Benefits
- Ester-terminated PLGA
- 85:15 lactide composition
- Slow degradation profile
- Extended drug release
- Lower hydrophilicity than acid-capped PLGA
- Improved hydrolytic stability
- Excellent drug encapsulation capability
- Excellent biocompatibility
- Available in multiple molecular weights
