N3-PEG-OH (Azide-PEG-Hydroxyl)

Description

General Description

N3-PEG-OH is a versatile heterobifunctional PEG building block designed for bioorthogonal conjugation and polymer functionalization. The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN, providing highly selective conjugation under mild conditions.

The terminal hydroxyl group can be readily converted into carboxylic acids, amines, NHS esters, aldehydes, acrylates, methacrylates, maleimides, thiols, epoxides, and many other functional groups, making N3-PEG-OH an important intermediate for synthesizing heterobifunctional PEG derivatives.

The hydrophilic PEG spacer provides excellent water solubility, molecular flexibility, and biocompatibility while minimizing nonspecific protein adsorption. N3-PEG-OH is widely employed in click chemistry, hydrogel preparation, nanoparticle engineering, surface modification, targeted drug delivery, and advanced biomaterials development.

Applications

• Click chemistry (CuAAC)
• Copper-free click chemistry (SPAAC)
• Polymer synthesis
• PEG linker synthesis
• Surface modification
• Nanoparticle functionalization
• Hydrogel synthesis
• Drug delivery systems
• Molecular imaging
• Biomaterials research

Features and Benefits

• Heterobifunctional PEG linker
• Reactive terminal azide group
• Terminal hydroxyl functionality
• Compatible with CuAAC chemistry
• Compatible with SPAAC chemistry
• Excellent water solubility
• Excellent biocompatibility
• Versatile synthetic intermediate
• Available in multiple PEG molecular weights