Azide-PEG-amine (N3-PEG-NH2) 

Description

General Description

N3-PEG-NH2 is a versatile heterobifunctional PEG linker designed for orthogonal bioconjugation and polymer functionalization. The terminal azide group participates in highly selective copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN, enabling efficient copper-free click chemistry under physiological conditions.

The terminal primary amine readily reacts with activated carboxylic acids through EDC/NHS coupling, as well as NHS esters, aldehydes, epoxides, isothiocyanates, and other electrophilic functional groups, allowing straightforward conjugation to proteins, peptides, antibodies, polymers, nanoparticles, and biomaterial surfaces.

The hydrophilic PEG spacer enhances water solubility, molecular flexibility, and biocompatibility while minimizing steric hindrance and reducing nonspecific protein adsorption. N3-PEG-NH2 is extensively used in click chemistry, protein conjugation, nanoparticle engineering, hydrogel synthesis, targeted drug delivery, molecular imaging, and advanced biomaterials development.

Applications

• Click chemistry (CuAAC)
• Copper-free click chemistry (SPAAC)
• Protein conjugation
• Antibody conjugation
• Peptide conjugation
• Polymer synthesis
• Nanoparticle functionalization
• Surface modification
• Drug delivery systems
• Biomaterials research

Features and Benefits

• Reactive azide group
• Terminal primary amine
• Compatible with CuAAC click chemistry
• Compatible with SPAAC chemistry
• Efficient amine conjugation
• Excellent water solubility
• Excellent biocompatibility
• Orthogonal bioconjugation
• Available in multiple PEG molecular weights