Description
General Description
N3-PEG-COOH (Azide-PEG-Carboxyl) is a versatile heterobifunctional PEG linker designed for orthogonal bioconjugation and polymer functionalization. The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN, allowing rapid and highly selective conjugation under mild conditions.
The terminal carboxylic acid group can be readily activated using carbodiimide chemistry (EDC/NHS) or peptide coupling reagents to react with primary amines on proteins, peptides, antibodies, polymers, nanoparticles, and biomaterial surfaces, forming stable amide bonds.
The hydrophilic PEG spacer enhances water solubility, molecular flexibility, and biocompatibility while minimizing steric hindrance and reducing nonspecific protein adsorption. N3-PEG-COOH is extensively used in click chemistry, protein conjugation, nanoparticle engineering, hydrogel synthesis, targeted drug delivery, molecular imaging, and advanced biomaterials development.
Applications
- Click chemistry (CuAAC)
- Copper-free click chemistry (SPAAC)
- Protein conjugation
- Antibody conjugation
- Peptide conjugation
- Polymer synthesis
- Nanoparticle functionalization
- Surface modification
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Reactive azide group
- Terminal carboxylic acid group
- Compatible with CuAAC click chemistry
- Compatible with SPAAC chemistry
- Efficient EDC/NHS coupling
- Excellent water solubility
- Excellent biocompatibility
- Orthogonal bioconjugation
- Available in multiple PEG molecular weights
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