n3-peg-sh

N3-PEG-SH (Azide-PEG-Thiol)

Price range: $360.00 through $800.00

N3-PEG-SH (Azide-PEG-Thiol) is a heterobifunctional polyethylene glycol (PEG) derivative containing a terminal azide (N3) group and a terminal thiol (SH) group. The azide functionality enables highly efficient click chemistry with alkyne- or DBCO-containing molecules, while the thiol group reacts selectively with maleimides, vinyl sulfones, activated disulfides, acrylates, and gold surfaces. N3-PEG-SH is widely used in click chemistry, bioconjugation, nanoparticle functionalization, drug delivery, and biomaterials research.

Product Name: N3-PEG-SH (Azide-PEG-Thiol)
Alternative Name: Azide-PEG-SH, SH-PEG-N3
Molecular Weight: 1000, 2000, 3400, 5000, 10000 Da, Custom
Functional Groups: Azide (N3), PEG, Thiol (SH)
Appearance: White to off-white solid
Solubility: Water, PBS, Methanol, DMSO, DMF
Storage: -20°C, dry and protected from moisture
Purity: Typically ≥95%

n3-peg-sh

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SKU: 9371 Categories: , , ,

Description

General Description

N3-PEG-SH (Azide-PEG-Thiol) is a versatile heterobifunctional PEG linker designed for orthogonal bioconjugation and advanced polymer functionalization. The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN, allowing highly selective conjugation under mild conditions.

The terminal thiol group reacts efficiently with maleimides to form stable thioether bonds and also participates in thiol-ene reactions, Michael addition, disulfide exchange, and self-assembly on gold nanoparticles and gold-coated surfaces through strong gold-sulfur interactions.

The hydrophilic PEG spacer enhances water solubility, molecular flexibility, and biocompatibility while reducing steric hindrance and minimizing nonspecific protein adsorption. N3-PEG-SH is extensively employed in click chemistry, hydrogel synthesis, biosensor fabrication, nanoparticle engineering, molecular imaging, targeted drug delivery, and advanced biomaterials development.

Applications

  • Click chemistry (CuAAC)
  • Copper-free click chemistry (SPAAC)
  • Thiol-maleimide conjugation
  • Gold nanoparticle functionalization
  • Surface modification
  • Hydrogel synthesis
  • Nanoparticle engineering
  • Molecular imaging
  • Drug delivery systems
  • Biomaterials research

Features and Benefits

  • Reactive azide group
  • Reactive terminal thiol group
  • Compatible with CuAAC click chemistry
  • Compatible with SPAAC chemistry
  • Efficient thiol conjugation
  • Excellent water solubility
  • Excellent biocompatibility
  • Orthogonal bioconjugation
  • Available in multiple PEG molecular weights

Additional information

Molecular weight

1000, 2000, 3400, 5000, 10K
Package size

200mg, 1g

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