Description
General Description
N3-PEG-Lipoic Acid (N3-PEG-LA) is a multifunctional PEG linker designed for combining bioorthogonal click chemistry with robust gold surface immobilization. The terminal azide group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes and strain-promoted azide-alkyne cycloaddition (SPAAC) with strained alkynes such as DBCO and BCN. These highly selective reactions proceed under mild conditions and are widely employed in bioconjugation and materials science.
The terminal lipoic acid moiety contains a cyclic disulfide that forms strong sulfur-gold interactions with gold nanoparticles, gold electrodes, and other noble metal surfaces. Compared with conventional monothiol ligands, lipoic acid generally provides enhanced anchoring stability and improved resistance to ligand exchange.
The hydrophilic PEG spacer improves aqueous solubility, molecular flexibility, and biocompatibility while reducing steric hindrance and minimizing nonspecific protein adsorption. N3-PEG-Lipoic Acid is extensively used in gold nanoparticle functionalization, biosensor fabrication, molecular imaging, targeted drug delivery, surface engineering, and nanomedicine research.
Applications
- Click chemistry (CuAAC)
- Copper-free click chemistry (SPAAC)
- Gold nanoparticle functionalization
- Gold surface modification
- Biosensor fabrication
- Surface PEGylation
- Nanoparticle engineering
- Molecular imaging
- Drug delivery systems
- Biomaterials research
Features and Benefits
- Reactive terminal azide group
- Stable lipoic acid gold anchor
- Compatible with CuAAC click chemistry
- Compatible with SPAAC chemistry
- Strong and stable gold surface binding
- Excellent water solubility
- Excellent biocompatibility
- Reduced nonspecific protein adsorption
- Available in multiple PEG molecular weights
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