Description
General Description
PLGA-PEG-Mal is a heterofunctional amphiphilic block copolymer designed for the preparation of biodegradable nanocarriers and targeted drug delivery systems. The PLGA segment provides a biodegradable hydrophobic core suitable for encapsulation of hydrophobic drugs, while the PEG segment forms a hydrophilic corona that improves colloidal stability, reduces protein adsorption, and prolongs circulation time.
The terminal maleimide group selectively reacts with thiol-containing peptides, antibodies, proteins, aptamers, and targeting ligands under mild conditions to form stable thioether linkages. This functionality enables the preparation of targeted nanoparticles, ligand-modified drug delivery systems, and functional biomaterials for pharmaceutical and biomedical applications.
Applications
- Nanoparticle formulation
- Polymeric micelle preparation
- Targeted drug delivery
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Surface functionalization
- Gene delivery research
- Controlled drug release
- Nanomedicine research
Features and Benefits
- Biodegradable PLGA segment
- Hydrophilic PEG spacer
- Reactive maleimide group for thiol conjugation
- Forms stable thioether linkages
- Excellent biocompatibility
- Reduces protein adsorption
- Improves nanoparticle stability
- Prolongs circulation time
- Suitable for targeted drug delivery
