Description
General Description
PLGA-PEG-NHS is a functional biodegradable copolymer designed for nanoparticle engineering and bioconjugation applications. The hydrophobic PLGA segment forms the core of nanoparticles and polymeric micelles capable of encapsulating hydrophobic drugs, proteins, peptides, nucleic acids, and imaging agents. The PEG segment forms a hydrophilic corona that improves colloidal stability, prolongs circulation time, and reduces nonspecific protein adsorption.
The terminal NHS ester readily reacts with primary amines on proteins, peptides, antibodies, aptamers, fluorophores, targeting ligands, and biomaterial surfaces under mild conditions to form stable amide bonds. This enables efficient preparation of targeted nanoparticles and functional drug delivery systems.
PLGA-PEG-NHS is widely employed in active targeting, antibody-conjugated nanoparticles, peptide-functionalized nanocarriers, molecular imaging, tissue engineering, and advanced nanomedicine applications.
Applications
- Drug delivery systems
- Nanoparticle formulation
- Polymeric micelle preparation
- Antibody conjugation
- Peptide conjugation
- Protein conjugation
- Targeted drug delivery
- Surface modification
- Tissue engineering
- Nanomedicine research
Features and Benefits
- Biodegradable PLGA segment
- Hydrophilic PEG spacer
- Reactive NHS ester functionality
- Efficient amine-specific conjugation
- Forms stable amide bonds
- Excellent biocompatibility
- Improves nanoparticle stability
- Extends circulation time
- Supports controlled drug release
