Biotin-PEG-PLL structure

PLL-PEG-Biotin

Price range: $360.00 through $1,200.00

PLL-PEG-Biotin is a functional graft copolymer consisting of poly(L-lysine) (PLL) modified with polyethylene glycol (PEG) terminated with biotin. The cationic PLL backbone provides excellent interaction with negatively charged biomolecules and cell surfaces, while PEG improves water solubility, biocompatibility, and colloidal stability. The terminal biotin enables high-affinity binding to streptavidin and avidin, making PLL-PEG-Biotin an ideal reagent for surface modification, biosensors, targeted drug delivery, and biomaterials research.

Product Name: PLL-PEG-Biotin
Alternative Name: Poly(L-Lysine)-PEG-Biotin, PLL-g-PEG-Biotin
Polymer Composition: Poly(L-Lysine)-graft-Polyethylene Glycol-Biotin
PLL Repeating Units: 20, 50, 100, 200, 500, Custom
PEG Molecular Weight: 550, 1000, 2000, 3400, 5000 Da, Custom
PEG Grafting Ratio: Customizable
Functional Groups: Poly(L-Lysine), PEG, Biotin
Appearance: White to off-white powder or lyophilized solid
Solubility: Water, PBS
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

Biotin-PEG-PLL structure

 

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SKU: 28274 Categories: , ,

Description

General Description

PLL-PEG-Biotin is a multifunctional PEGylated polypeptide designed for bioconjugation and biointerface engineering. The poly(L-lysine) backbone contains multiple primary amine groups that readily adsorb onto negatively charged substrates such as glass, silica, metals, and polymeric materials, while also interacting electrostatically with nucleic acids and proteins.

The PEG spacer enhances aqueous solubility, reduces nonspecific protein adsorption, minimizes aggregation, and improves biocompatibility. The terminal biotin group binds with exceptionally high affinity to streptavidin and avidin, enabling efficient immobilization of antibodies, enzymes, peptides, nucleic acids, nanoparticles, and other biotinylated or streptavidin-functionalized biomolecules.

PLL-PEG-Biotin is widely employed in biosensor fabrication, cell culture surface modification, nanoparticle functionalization, diagnostic assays, tissue engineering, molecular imaging, and targeted drug delivery.

Applications

  • Surface modification
  • Biosensor fabrication
  • Streptavidin immobilization
  • Avidin-biotin conjugation
  • Cell culture surface coating
  • Nanoparticle functionalization
  • Drug delivery systems
  • Tissue engineering
  • Diagnostic assay development
  • Biomaterials research

Features and Benefits

  • Poly(L-lysine) backbone
  • High-affinity biotin functionality
  • Hydrophilic PEG spacer
  • Excellent surface adsorption
  • Reduced nonspecific protein adsorption
  • Improved colloidal stability
  • Excellent biocompatibility
  • Compatible with streptavidin and avidin systems
  • Available with customizable PEG substitution

Additional information

MW of PLL

3300 (x=20), 8200 (x=50), 16K (x=100), 32K(x=200)
MW of PEG

1000, 2000, 5000
Pakage size

50mg, 100mg, 500mg

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