Description
General Description
Silane-PEG-Azide (Silane-PEG-N₃) is a heterobifunctional polyethylene glycol derivative containing a surface-reactive silane group at one end and a click-reactive azide group at the other.
The silane functionality can hydrolyze and condense with hydroxyl groups on suitable inorganic surfaces, enabling PEG modification of materials such as glass, silica, silicon oxide, and other hydroxylated metal oxide surfaces.
The terminal azide remains available for subsequent functionalization using copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkynes or strain-promoted azide-alkyne cycloaddition (SPAAC) with strained cyclooctynes such as DBCO and BCN.
The PEG spacer provides a hydrophilic and flexible separation between the modified surface and the terminal azide, making Silane-PEG-N₃ useful for surface bioconjugation, biosensors, nanoparticles, biomaterials, and immobilization applications.
Applications
- Glass and silica surface modification
- Silicon oxide functionalization
- Metal oxide surface modification
- Surface PEGylation
- CuAAC click chemistry
- Copper-free SPAAC click chemistry
- Biomolecule immobilization
- Protein and peptide conjugation
- Biosensor functionalization
- Nanoparticle surface modification
- Biointerface engineering
- Biomaterials research
Features and Benefits
- Surface-reactive silane functionality
- Terminal azide (N₃)
- Hydrophilic PEG spacer
- Suitable for hydroxylated inorganic surfaces
- Compatible with CuAAC click chemistry
- Compatible with copper-free SPAAC
- Enables two-step surface functionalization
- Suitable for DBCO- and BCN-containing biomolecules
- Different PEG molecular weights available
- Custom specifications available
