Description
General Description
DMPE-PEG-COOH is a phospholipid–poly(ethylene glycol) conjugate containing DMPE (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, C14:0), a hydrophilic PEG spacer, and a terminal carboxylic acid functional group. The carboxyl group enables versatile conjugation and surface functionalization through amide coupling and esterification reactions.
Key Properties
- Carboxyl-functionalized lipid PEG conjugate
- Reactive terminal carboxylic acid group
- DMPE lipid anchor for membrane incorporation
- PEG spacer improves aqueous solubility and steric stabilization
- Biocompatible lipid–polymer hybrid material
Applications
- Liposome and lipid nanoparticle functionalization
- Surface modification of nanoparticles and biomaterials
- Drug delivery system development
- Biomolecule and polymer conjugation
- Hydrogel and polymer functionalization
- Targeted nanomedicine applications
Functional Overview
The DMPE lipid segment anchors into lipid bilayers, while PEG provides flexibility and stealth properties. The terminal carboxylic acid group enables conjugation with amine-containing molecules through carbodiimide-mediated coupling reactions.
Summary
DMPE-PEG-COOH is a versatile carboxyl-functional lipid PEG conjugate widely used in liposome engineering, bioconjugation, and advanced drug delivery applications.
