Description
General Description
DBCO-Amine (DBCO-NH2) is a multifunctional click chemistry reagent designed for copper-free bioorthogonal conjugation. The DBCO moiety reacts rapidly and selectively with azide-containing compounds under physiological conditions without the need for copper catalysts, making it highly suitable for biological systems, live-cell labeling, and in vivo applications.
The terminal primary amine group serves as a versatile handle for conjugation with activated esters, carboxylic acids, aldehydes, isothiocyanates, fluorophores, polymers, nanoparticles, proteins, peptides, and biomaterial surfaces. The resulting DBCO-functionalized molecules can subsequently react with azide-containing compounds through SPAAC click chemistry.
DBCO-Amine is frequently employed in antibody-drug conjugates, molecular imaging probes, biomaterial modification, nanoparticle engineering, protein labeling, cell-surface engineering, and advanced bioorthogonal chemistry research.
Applications
- Copper-free click chemistry
- SPAAC conjugation
- Antibody labeling
- Protein conjugation
- Peptide conjugation
- Nanoparticle functionalization
- Molecular imaging
- Cell-surface labeling
- Diagnostic assay development
- Biomaterials research
Features and Benefits
- Reactive DBCO functionality
- Copper-free click chemistry
- Rapid SPAAC reaction kinetics
- Reactive primary amine group
- Excellent bioorthogonality
- Suitable for live-cell applications
- No copper catalyst required
- High conjugation efficiency
- Versatile synthetic intermediate
