DBCO-acid chemical structure

DBCO-Acid (DBCO-COOH)

Price range: $80.00 through $600.00

DBCO-Acid (DBCO-COOH) is a dibenzocyclooctyne derivative containing a terminal carboxylic acid group. The DBCO moiety enables rapid copper-free click chemistry with azide-containing molecules through strain-promoted azide-alkyne cycloaddition (SPAAC), while the carboxylic acid functionality provides a versatile reactive site for conjugation with amine-containing biomolecules. DBCO-Acid is widely used in bioconjugation, antibody labeling, nanoparticle functionalization, molecular imaging, diagnostics, and bioorthogonal chemistry applications.

Product Name: DBCO-Acid (DBCO-COOH)
Full Name: Dibenzocyclooctyne-Carboxylic Acid
CAS Number: 1353016-70-2
Molecular Weight: 305.3
Appearance: White to off-white solid
Solubility: DMSO, DMF, Methanol
Storage: -20°C, dry and protected from light
Purity: Typically ≥95%

DBCO-acid chemical structure

 

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Technical Data

CAS No.:1353016-70-2

Name: DBCO-acid

Formula:C19H15NO3

Purity: 98%

M. W.:  305.33

Description

General Description

DBCO-Acid (DBCO-COOH) is a multifunctional click chemistry reagent designed for copper-free bioorthogonal conjugation. The DBCO moiety reacts rapidly and selectively with azide-containing molecules under physiological conditions without the need for copper catalysts, making it highly suitable for biological systems, live-cell labeling, and in vivo applications.

The terminal carboxylic acid group can be activated using EDC/NHS chemistry to conjugate proteins, peptides, antibodies, enzymes, nucleic acids, fluorophores, nanoparticles, and other amine-containing molecules. The resulting DBCO-functionalized biomolecules can subsequently react with azide-containing compounds through SPAAC click chemistry.

DBCO-Acid is frequently employed in antibody-drug conjugates, molecular imaging probes, biomaterial modification, nanoparticle engineering, cell-surface labeling, and advanced bioorthogonal chemistry research.

Applications

  • Copper-free click chemistry
  • SPAAC conjugation
  • Antibody labeling
  • Protein conjugation
  • Peptide conjugation
  • Nanoparticle functionalization
  • Molecular imaging
  • Cell-surface labeling
  • Diagnostic assay development
  • Biomaterials research

Features and Benefits

  • Reactive DBCO functionality
  • Copper-free click chemistry
  • Rapid SPAAC reaction kinetics
  • Reactive carboxylic acid group
  • Compatible with EDC/NHS coupling chemistry
  • Excellent bioorthogonality
  • Suitable for live-cell applications
  • No copper catalyst required
  • High conjugation efficiency

Additional information

Package Size

50mg, 100mg, 200mg, 1g

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