Price range: $80.00 through $600.00
DBCO-NHS is a dibenzocyclooctyne derivative containing an N-hydroxysuccinimide (NHS) ester. The DBCO moiety enables rapid copper-free click chemistry with azide-containing molecules through strain-promoted azide-alkyne cycloaddition (SPAAC), while the NHS ester provides efficient conjugation with primary amine-containing biomolecules. DBCO-NHS is widely used in bioconjugation, antibody labeling, protein modification, molecular imaging, diagnostics, and bioorthogonal chemistry applications.
APPEARANCE (COLOR) off white to slight yellow
APPEARANCE (FORM) solid
PURITY (HPLC %) 98 %
PROTON NMR SPECTRUMÂ Â Â conforms to structure
CAS Number:Â 1353016-71-3
 FORMULA  C23H18N2O5
MOLECULAR WEIGHT:Â 402.4
SHIPPING CONDITION Ambient Temperature
DBCO-NHS is a highly reactive click chemistry reagent designed for copper-free bioorthogonal conjugation. The DBCO group reacts rapidly and selectively with azides under physiological conditions without requiring copper catalysts, making it ideal for biological systems, live-cell labeling, and in vivo applications.
The NHS ester readily reacts with primary amines on proteins, antibodies, peptides, enzymes, nucleic acids, nanoparticles, and biomaterial surfaces to form stable amide bonds. This allows efficient introduction of DBCO functionality onto biomolecules, which can subsequently undergo SPAAC click reactions with azide-containing compounds.
DBCO-NHS is frequently employed in antibody-drug conjugates (ADCs), protein labeling, molecular imaging probes, nanoparticle engineering, biomaterial functionalization, cell-surface modification, and advanced bioorthogonal chemistry research.
| Package Size | 50mg, 100mg, 200mg, 1g |
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