Description
General Description
DMG-PEG-Maleimide (DMG-PEG-Mal) is a reactive PEGylated lipid conjugate containing dimyristoyl glyceride (DMG, C14:0), polyethylene glycol (PEG), and a terminal maleimide functional group. The maleimide functionality reacts selectively with thiol-containing molecules under mild conditions to form stable thioether linkages for nanoparticle surface engineering and bioconjugation applications.
Key Properties
- Maleimide-functionalized PEGylated lipid
- Reactive toward thiol-containing molecules
- Dimyristoyl glyceride lipid anchor (C14:0)
- Amphiphilic structure for nanoparticle stabilization
- Widely used in LNP and liposome formulations
Applications
- Thiol-mediated bioconjugation
- Lipid nanoparticle (LNP) engineering
- Liposome surface modification
- Antibody and peptide conjugation
- Drug and nucleic acid delivery
- Nanomedicine and biomaterial applications
Functional Overview
The DMG lipid segment enables membrane incorporation, while the PEG chain improves steric stabilization and nanoparticle performance. The terminal maleimide group enables selective conjugation with thiol-containing biomolecules and nanoparticle surfaces.
Summary
DMG-PEG-MAL is a versatile thiol-reactive PEGylated lipid widely used in lipid nanoparticle engineering, bioconjugation, and advanced nanomedicine applications.
